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1·GJB2 gene knockout mice led to death during embryonic period.

GJB2基因敲除小鼠在胚胎期致死。

2·BPOZ gene knockout leads to es cell growth suppression and has no significant influence on es cell differentiation.

BPOZ基因剔除使es细胞生长受抑，对ES细胞分化发育没有明显影响。

3·Objective Serum lipid and histopathological status were observed in apoE gene knockout mice of different genders and ages.

目的观察我部饲养的不同年龄、不同性别的载脂蛋白E基因缺陷小鼠的血脂及病理组织学状况。

4·Objective: To study the effects of water extract from Paris Polyphylla Smith on advanced plaques in ApoE gene knockout mice.

目的研究蚤休水提液对载脂蛋白E基因敲除小鼠晚期斑块的影响。

5·The widespread use of gene knockout technology promotes the course of the research of gene function in post genomic era greatly.

基因敲除技术的广泛应用，极大地推动了后基因组时代对于基因功能研究的进程。

6·In this paper, the basic principles of gene knockout, several common techniques and their application in microbial breeding were introduced.

论述了基因敲除的基本原理、几种常用技术及该项技术在微生物育种方面的应用。

7·In addition, several useful laboratory techniques, e. g. small RNA interference and gene knockout are comprehensively introduced during the lecture.

同时，课程也将对RNA干扰和基因敲除等重要的实验技术的原理及应用作专题介绍。

8·Objective: To establish a highly efficient production system of chimeras by perfecting and normalizing the key steps of technology system of gene knockout mice.

目的：完善和规范基因剔除小鼠技术体系的关键技术环节，建立一套高效的嵌合体制备体系。

9·This paper introduced the principle, the targeting strategies, the screening mechanism and the commonly method in animals, plants and micro-organisms of gene knockout.

本文简述了基因敲除技术的基本原理、打靶策略、筛选机制，在动植物和微生物中常用的基因敲除方法以及基因敲除的应用。

10·The technology system of gene knockout mice is a most urgently needed technique in the life science research, especially in human genomic project and medical animal models research.

基因剔除小鼠的技术体系是生命科学研究，尤其是人类基因组计划和医学实验动物模型等领域所急需的关健技术。