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1·What is the function of ligase in DNA replication?

什么是连接酶的作用在脱氧核糖核酸复制的？

2·The breast cancer susceptibility gene, BRCA1, codes for an E3 ubiquitin ligase that functions in the maintenance of genome stability through regulation of the DNA damage response and DNA repair.

乳腺癌易感基因，BRCA1，编码一种E3泛素连接酶，BRCA1通过调控DNA损伤反应和DNA修复维持基因组的稳定性。

3·Methods TLR2 gene polymorphisms were analyzed by DNA sequencing in a small amount of samples. SNPs in TLR2 gene were detected by ligase detection technique in a large amount of samples.

方法在小样本中测序检测TLR2基因中可能存在的基因多态性，再用连接酶特异检测技术在大样本进行SNP分型，并通过统计学方法分析基因多态性与结核病易感性之间相关性。

4·The breast cancer susceptibility gene, BRCA1, codes for an E3 ubiquitin ligase that functions in the maintenance of genome stability through regulation of DNA damage response and DNA repair.

乳腺癌易感基因，BRCA1，编码一种E3泛素连接酶，BRCA1通过调控DNA损伤反应和DNA修复维持基因组的稳定性。