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1·Results: Significant improvement of dissolution of tolbutamide was found.

结果：甲苯磺丁脲片的溶出度有很大程度提高。

2·Methods: L-HPC was added into tolbutamide and its dissolution was measured.

方法：于甲苯磺丁脲中加入低取代羟丙基纤维素测定溶出度。

3·P450 2c9 substrates mainly include tolbutamide, phenytoin, S-warfarin, fluoxetine, and losartan.

P 4 5 0 2c9的底物包括甲苯磺丁脲、苯妥英、s法华令、氟西汀、洛沙坦等。

4·AIM to establish a reverse phase high-performance liquid chromatography (RP-HPLC) method to determine the level of tolbutamide in human plasma.

目的：建立反相高效液相色谱法测定人血浆中甲磺丁脲含量的方法。