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1·The saddening part was that it was a lifelong disease.

令人悲哀的是，这是一种终生疾病。

2·It is saddening to see that relations between the two countries should have deteriorated to the present state.

两国关系恶化到今天这个地步，是令人痛心的。《新英汉大辞典》

3·But this really saddening …

这件是真的很突然…

4·I find public squalor very saddening.

公共场所的肮脏污秽让我感到非常悲哀。

5·Ignorance is more saddening than poverty.

无知比贫穷更可悲。

6·News of such a decline, published today in Current Biology, would be saddening in any species.

今天出版的《当代生物学》报道说，族群数量这样的骤降对于任何一种生物都是悲哀的。

7·It's really saddening for her to find out a year later that she's right back where she started.

一年之后她很伤心的发现自己又走回了原来的老路。

8·In fact, there is nothing more saddening for a depressed person than to hear statements like these.

事实上，对于抑郁患者来说，没有什么比听到这些话更令人难过的了。

9·It was saddening to think how man is spoiling this environment by over-fishing, and illegal fishing.

想想人类过度捕捞和非法捕捞对环境造成的破坏，真是让人痛心。

10·It is the same for everyone throughout the world, but losing a member of the family is very saddening.

这对全世界所有人来说都是一样的，但失去一位家人令人悲痛万分。

难过

1·A lot of stuff is represented from varying sides and is sometimes very uplifting and very, very saddening.

很多东西是代表从不同方面和有时是很向上的和非常，非常难过。

2·In fact, there is nothing more saddening for a depressed person than to hear statements like these.

事实上，对于抑郁患者来说，没有什么比听到这些话更令人难过的了。