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1·MAIN OUTCOME MEASURES: Effect of PNS on distribution of cholinergic neuron and ChAT content in cerebral tissue of AD rat models.

主要观察指标：三七总皂苷对阿尔茨海默病大脑胆碱能神经元分布和胆碱乙酰基转移酶的影响。

2·To study nerve stem cell directional differentiation to cholinergic neuron by adjusting action of promote differentiation factors.

目的通过促分化因子的调节作用对神经干细胞向胆碱能神经元的定向分化进行探讨研究。

3·DR increases the expression of syn of cortical and hippocampal neurons by improving the injury of cholinergic neuron to recovery the function of synaptic transmission.

地黄饮子能通过改善鼠脑神经元胆碱能损害，来上调海马和皮层神经元syn蛋白的表达，使突触传递功能恢复。

4·The change of ultra-structure in cerebral cortex microcirculation can induce the dysfunction of cholinergic neuron and further cause the exercise-induced central fatigue.

大脑组织这种形态结构的改变可能导致其神经元功能障碍，进而引起运动性中枢疲劳的发生。

5·Objective: to observe the protective effect of Panax notoginseng saponins (PNS) against pathological lesion of cholinergic neuron in rat model with Alzheimer's disease (AD).

目的：观察三七总皂苷(PNS)对老年性痴呆(AD)大鼠模型大脑胆碱能神经病理损害的保护作用。

6·Observation the space-time change of cortex nerve stem cell in newborn rat orientation differentiation to cholinergic neuron by cell cultured and immunocyte chemistry methods.

方法采用细胞培养技术、免疫细胞化学方法观察新生大鼠皮层神经干细胞向胆碱能神经元定向分化的时空变化。