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1·Aim To observe the expression of cyclooxygenase COX-1 and 2 in brain after spared nerve injury (SNI).

目的观察坐骨神经损伤(SNI)后小鼠脑环氧合酶cox - 1和2的表达变化。

2·To observe the expression of cyclooxygenase (COX) -1 and COX-2 in brain after spared nerve injury (SNI) and compare the analgesic effects of COX inhibitors with different selectivity.

为了观察坐骨神经损伤(SNI)后小鼠全脑环氧合酶(COX) - 1和COX - 2的表达变化，以及不同选择性的COX抑制剂对SNI所致神经病理性痛的效应。