全部

1·Conclusion Affinity maturation might have been completed by the time that patients presented with anti-GBM disease.

结论起病时抗gbm抗体的亲合力成熟过程已经完成。

2·Conclusion Error-prone PCR is an effective and simple method for affinity maturation of antibodies isolated from a phage antibody library.

结论错配pcr结合噬菌体展示技术是提高单链抗体亲和力的一种有效且简便的手段。

3·As an effective method of studying soluble protein-protein interactions, yeast display system is now widely used for affinity maturation of single-chain antibodies.

酵母展示系统是研究可溶性蛋白间相互作用的有效系统。

4·A parallel optimization algorithm is proposed based on the idea of affinity maturation of immune cells in the germinal centers in order to achieve as many as possible local optimal solutions.

为此 ，研究了产品与过程设计活动之间的并行度优化问题 ，并建立了数学模型 ，给出了求解该问题的算法 ，其目的是使因延迟产品开发完成时间和不必要的设计修改而带来的成本尽可能最低。

5·Because this method was to simulate the process of antibody maturation in vivo, the obtained antibodies was not only fully humanized but also with relatively high affinity.

该方法体外模拟了抗体亲和力成熟的过程，使得到的抗体不但可以完全的人源化，而且可以具有较高的亲和力。