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1·Have you run up against any problems in getting your passport renewed?

你在护照续签时遇到什么问题了吗？

2·Don't back up the moment you run up against a little difficulty.

不要遇到一点困难就打退堂鼓。《新英汉大辞典》

3·We've run up against a big problem .

我们碰到了一个大问题。

4·But this would run up against Putin and Russia's veto.

但是这会遭到普京的反对，俄罗斯会投反对票。

5·You can't give up the moment you run up against difficulty.

不能遇到点困难就打退堂鼓呀。

6·In keeping a diary in English, we inevitably run up against a lot of difficulties.

坚持用英语写日记，我们不可避免地要遇到很多困难。

7·If you try to change the name of the school you will run up against a lot of opposition.

倘若你要更换学校的名称，你会遭到多人的反对。

8·If he tries to change the rules of the club he will run up against a lot of opposition.

如果他想改变俱乐部的章程，就会遇到很多反对意见。

9·Also, if you run up against obstacles, it is critical to let management know right away.

同时，如果你碰到的障碍，关键是要让管理层知道吧。

10·Every time we try to get the scheme going we seem to run up against yet another problem.

我们每次试图执行计划时，似乎又碰到了另一个困难。