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1·Objective To explore germline mutation frequencies and features of mismatch repaired gene MSH6 in persons with different kinds of colorectal cancer.

目的了解错配修复基因MSH6在不同形式大肠癌人群中的种系突变频率及特征，提供真正的突变热点。

2·Often the result of a new germline or somatic mutation.

通常源于种系的新突变或体细胞突变。