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1·The famine threatened to depopulate the continent.

饥荒威胁着该大陆人口数量。《柯林斯英汉双解大词典》

2·Keep in mind: at the start of this century, many experts predicted that AIDS would depopulate the African region, raising the prospect of state failure in the hardest-hit places.

要知道，本世纪之初时，许多专家曾预言艾滋病将使非洲区域人口减少，并指出受影响最严重地区的国家将面临失败的前景。