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1·Isothiocyanatoacetate ester is synthesized by the reaction of aminoacetic acid with carbon disulfide and ethyl chloroformate in the presence of an alkali with the overall yield of 48.

在碱性条件下，用氨基乙酸与二硫化碳、氯甲酸乙酯反应合成了异硫氰基乙酸乙酯，总收率为4 8。