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1·The common character of human tumor is genomic instability.

基因组不稳定是人类肿瘤的特征。

2·Conclusion The occurrence of melanoma might be associated with genetic genomic instability.

结论黑色素瘤的发生可能与基因组不稳定性有关。

3·CONCLUSION: Crystalline nickel sulfide could induce genomic instability in the 16hbe cells induced by nickel acetate.

结论：乙酸镍能诱发16hbe细胞基因组不稳定。

4·When function defects of mismatch repair genes, Cell Showes Genomic instability because of the aggregation of mutation.

错配修复基因功能缺失时，细胞常会因基因突变聚集而表现为遗传不稳定。

5·There are several reasons why this might be, including the capacity of hypoxia to drive genomic instability and alter DNA damage repair pathways.

有很多原因可以解释，包括：乏氧驱使基因组不稳定性及改变DNA损伤修复通路的能力。

6·Etoposide stabilizes a covalent topoisomerase II-cleaved DNA intermediate complex in the catalytic cycle of the enzyme, leading to genomic instability and cell death (2, 3).

依托泊苷能稳定酶催化性循环中的一种共价的拓扑异构酶ii裂解的DNA中间复合物，导致基因组不稳定性和细胞死亡(2,3)。

7·There is still much debate on the distinct classes of genomic instability and their specific roles in the initiation of tumor formation, as well as in the progressive transition to a cancerous state.

众多学者认为， 遗传物质的微卫星不稳定性可导致肿瘤的发生，尤其在恶性肿瘤的发生中有特殊作用。