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1·Intravenous injection with endotoxin of E. coli and intramuscular injection with methylprednisolone were used to establish the ONF rabbit model.

利用静脉注射大肠杆菌内毒素及肌肉注射甲基强的松龙，建立兔onf动物模型。

2·At the end of the experiment, the rabbits were sacrificed, and determined the occurrence of ONF by observed the pathology of femoral head and the changes of bone histomorphology.

实验终点处死动物观察股骨头大体病理及骨组织形态学改变判断ONF发生情况。