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1·The long term toxicity test also indicated that this drug has low toxicity and wide safe range.

长期毒性实验也表明本品毒性低、安全范围大。

2·The long term toxicity test showed that use high dose of TAH for long time can produce reversible nephrotoxicity.

毒性研究表明长期大剂量tah可引起可逆性肾毒性。

3·Long term toxicity test did not confirm any adverse effects, and the maximal dosage was 40 times more than the human use in clinic.

长期毒性试验证明，对大鼠无毒副作用，其最大用量为人体用量的4 0倍以上。

4·Meanwhile guinea pigs and rabbits were selected separately to carry out skin acute toxicity test and long term toxicity test, skin stimulative test and allergic test.

同时选择豚鼠及家兔分别进行烧伤酊的皮肤急性毒性试验，皮肤长期毒性试验，皮肤刺激试验及皮肤过敏试验。

5·The acute toxicity test and long-term toxicity test show that the capsules have no toxic effects and side effects, it is safe and reliable for clinic.

急性毒性、长期毒性实验证明本品无毒副作用，临床口服用药安全可靠；

6·Methods: the toxicity was observed in the acute toxicity test, the long-term toxicity test, the dermal irritation test and the dermal allergy test.

方法：皮肤急性毒性试验，皮肤长期毒性试验，皮肤刺激性试验，皮肤过敏试验。

7·Evaluated the biocompatibility through the experiments including a cute systemic toxicity test, pyrogen, intracutaneous test and long-term muscle and bone implant test.

方法分别进行急性毒性试验、热原试验、皮内试验、肌肉植入试验、骨植入试验等生物相容性试验。

8·Detects the toxicological action of Aloe by acute toxicity test, maximum dosage and long-term toxicity test.

采用最大给药量及长期毒性测定芦荟毒性作用。

9·ConclusionTheacrine has no significant toxicity in long-term toxicity test to rats, which inferrs that the drawing up dose in clinic is safe.

结论苦茶碱长期用药对大鼠无明显毒性，按临床拟用剂量服用是安全的。