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1·The results showed that percutaneous fluxes of 1 in pH7.4 phosphate buffer solution with anodal and cathodal iontophoresis were 230% and 45% of that of the passive diffusion flux respectively.

结果表明，1生理盐水饱和液阳极导入时的透皮速率是被动扩散的2．3倍，阴极导入时药物的透皮速率是其被动扩散的45％，说明电渗作用明显促进了分子型药物1的经皮渗透；